For people suffering from Orthostatic Intolerance, Postural Orthostatic Tachycardia, Mast Cell Activtation or EDS. Follow me as I document my struggle towards better health.

Wine, Postural Orthostatic Tachycardia and Orthostatic Intolerance

If you have POTS or OI you may have experienced a reaction to drinking wine.  At a time in your life when drinking a little wine could really be useful isn't it a nuisance that our bodies won't cooperate?

Here are some thoughts about why wine may produce or worsen symptoms:

Histamines ( important to note for those with Mastosystosis)
Certain wines contain high levels of histamines. Red wine can contain 20-200% more histamines than white wine.  According to one study the histamine levels in wine ranged from 3-120 microgrammes/l in white wine, 15-670 micog/l in champagnes, and 60-3800 microg /l in red wines.  Some countries have even published histamine limits for wine. Germany for example suggests 2mg/l as a limit.  Seems low as it would probably exclude most wines.  Germans are obviously biased beer drinkers.

I found this product called "Histame" which claims the following:
Naturally Vitamins’ new dietary ingredient (NDI), the Diamine Oxidase (DAO) enzyme, was acknowledged by the Food and Drug Administration in 2008. This breakthrough achievement offers hope to millions of Americans who suffer from histamine food intolerance.
If I could find this on the local pharmacy shelf I may try it with a glass of amarone.

My neurologist told me once that I should only drink pinot grigio because of my migraines.  He never said why though.  Further notes: Wines also contain prostoglandin which may cause vasoldilation and  tannins which cause the release of serotonin.  


  1. For me the problem in wine is the sulfites. I know this is true because when I was in Germany I drank the a wine that is made without sulfites, Franken, and never had a problem. Sulfite is added to improve flavor.

    'A number of studies show reactions by sensitive patients to drinking wine with sulfites....'


  2. Good point Jane! I did leave sulfites out (not sure why) but it certainly is a common source of intolerance too. Thanks for bringing it up. :-)